MBC
(2R,3S)-2-(3,4-二羟基苯基)苯并吡喃-3,5,7-三醇|Cianidanol
| PB00236-1g
纯度:97% ； 分子式:C15H14O6
M0703-74661
PB00236-1g
1g
154-23-4
C15H14O6
97%
¥291.00
¥208.00
1
3 天
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昀冠品质提供的(2R,3S)-2-(3,4-二羟基苯基)苯并吡喃-3,5,7-三醇 MBC(PB00236-1g) 性能卓越，竭诚为您服务。
| 英文名称* | Cianidanol |
|---|---|
| 中文名称 | (2R,3S)-2-(3,4-二羟基苯基)苯并吡喃-3,5,7-三醇 |
| 别名 | Catechuic acid, (+)-Catechin, Catechin, Catechinic acid, D-Catechin |
| 产品描述 | Catechin((+)-Catechin; D-Catechin) is a flavan-3-ol, a type of natural phenol and antioxidant. |
| 靶点活性 | COX-1 : ic50 80μM COX-2 : ic50 130μM |
| 体外活性 | The catechin flavonoid reduces proliferation and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins[1]. Treatment of human prostate cancer cells with catechin induces apoptosis and results in effects on a variety of survival signals suggesting the potential of these compounds as chemopreventive agents for prostate cancer[2]. Catechin is well known to inhibit cyclooxygenase activity with reported IC50 values ranging from 4O μM to 943 μM. It has also been reported to act as an inhibitor of COX-1 and COX-2 with IC50 of about 80 μM and 130 μM[3]. |
| 体内活性 | Dietary catechin significantly delayed tumor onset[5]. Continued intake of catechin, a potential antioxidant, prevents memory regression and DNA oxidative damage in senescence-accelerated (SAMP10) mice. It does not prolong the lifetime of SAMP10 mice, but it does delay brain senescence[6]. (+)-Catechin inhibits intestinal tumor formation and suppresses Focal adhesion kinase activation in the Min/+ Mouse[7]. |
| 细胞实验 | LB02 cells were resuspended in RPMI 10% FBS in a concentration of 5x105 cells/mL. The cultures were performed in 96-well round-bottomed microtitre plates in presence of different concentrations of catechin or rutin (10, 50, 100 or 200 μg/mL). After 48 h at 37 ºC in a humidified atmosphere with 5% CO2 in the air, cultures were pulsed with 1 μCi of 3H-thymidine/well and maintained for an additional 18 h period prior to a semiautomatic method harvest. (Only for Reference) Cell lines: LB02 tumor cell line |
| CAS | 154-23-4 |
| 纯度 | 97% |
| 分子量 | 290.27 |
| 分子式 | C15H14O6 |
| 溶解度 | DMSO: 54 mg/mL (186 mM) Ethanol: 54 mg/mL (186 mM) Water: 53 mg/mL (182.6 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble ) |
| 储存温度 | 0-4℃ for short term (days to weeks), or -20℃ for long term (months). |
| 品牌 | MBC |
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