MBC
土木香内酯|Helenine
| PB00138-25mg
纯度:98% ； 分子式:C15H20O2
M0703-80418
PB00138-25mg
25mg
546-43-0
C15H20O2
98%
¥149.00
¥106.00
1
3 天
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- 产品详情
昀冠品质提供的土木香内酯 MBC(PB00138-25mg) 性能卓越，竭诚为您服务。
| 英文名称* | Helenine |
|---|---|
| 中文名称 | 土木香内酯 |
| 别名 | Alant camphor, Inula camphor, (+)-Alantolactone, Alantolactone, helenin, Eupatal |
| 产品描述 | Alantolactone(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3) signaling pathway. |
| 靶点活性 | Others |
| 体外活性 | Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Alantolactone effectively suppressed both constitutive and inducible STAT3 activation at tyrosine 705. It decreased STAT3 translocation to the nucleus, its DNA-binding, and STAT3 target gene expression. Alantolactone significantly inhibits STAT3 activation with a marginal effect on MAPKs and on NF-κB transcription; however, this effect is not mediated by inhibiting STAT3 upstream kinases. SHP-1, SHP-2, and PTEN, which are protein tyrosine phosphatases (PTPs) were not affected by alantolactone. Alantolactone treatment resulted in the inhibition of migration, invasion, adhesion, and colony formation[1]. Alantolactone could induce activin signaling and activin target gene expression. Alantolactone activated the activin signaling pathway in a cancer cell line. It could promote SMAD2/3 nuclear translocation in a very short time[3]. |
| 体内活性 | In vivo administration of alantolactone inhibited the growth of human breast xenograft tumors[1]. Alantolactone exerts no toxic effect on liver and kidneys in vivo, The drug was well tolerated by mice and no mortality or any sign of pharmacotoxicity was found at a dose of 100 mg/kg during all the experimental periods. Alantolactone can cross blood-brain barrier[2]. |
| 细胞实验 | Cell viability was evaluated using MTT assay. The cells were seeded into 96-well plates and maintained at 37 °C for 24 h. The cells were treated with alantolactone for 24 h. The MTT solution (0.5 mg/mL) was added to each well, and the cells were incubated for another 3 h. The MTT formazan crystals were dissolved in DMSO. The results were obtained by measuring the absorbance at a wavelength of 540 nm using a microplate reader.(Only for Reference) Cell lines: MDA-MB-231 and MCF-7 cells |
| CAS | 546-43-0 |
| 纯度 | 98% |
| 分子量 | 232.33 |
| 分子式 | C15H20O2 |
| 溶解度 | DMSO: 23.2 mg/mL (100 mM) Ethanol: 46 mg/mL (198 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble ) |
| 储存温度 | 0-4℃ for short term (days to weeks), or -20℃ for long term (months). |
| 品牌 | MBC |
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