MBC
3-(10,11-二氢-5H-二苯并[a,d][7]轮烯-5-亚基)-N,N-二甲基丙-1-胺盐酸盐|Amitriptyline hydrochloride
| PB01518-5g
分子式:C20H24ClN
![3-(10,11-二氢-5H-二苯并[a,d][7]轮烯-5-亚基)-N,N-二甲基丙-1-胺盐酸盐](/upload/product/cas/600/549-18-8.jpg)
M0703-80490
PB01518-5g
5g
549-18-8
C20H24ClN
¥437.00
¥437.00
1
请咨询
售前咨询：sales@ygsci.com
电话咨询：4000-876-099
- 产品详情
昀冠品质提供的3-(10,11-二氢-5H-二苯并[a,d][7]轮烯-5-亚基)-N,N-二甲基丙-1-胺盐酸盐 MBC(PB01518-5g) 性能卓越，竭诚为您服务。
| 英文名称* | Amitriptyline hydrochloride |
|---|---|
| 中文名称 | 3-(10,11-二氢-5H-二苯并[a,d][7]轮烯-5-亚基)-N,N-二甲基丙-1-胺盐酸盐 |
| 别名 | Amitriptyline HCl, Annoyltin, Tryptizol, Domical |
| 产品描述 | Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. |
| 靶点活性 | 5-HT : ic50 3.45nM 5-HT2 : ic50 235nM 5-HT4 : ic50 7.31nM Norepinephrine receptor : ic50 13.3nM σ1 : ic50 287nM |
| 体外活性 | Amitriptyline inhibits Forskolin-stimulated cyclic AMP accumulation with EC50 values of 16.2 μM in intact CHO/DOR cells. Amitriptyline causes a concentration-dependent stimulation of ERK1/2 and GSK-3β phosphorylation with EC50 values of 9.0 μM in CHO/DOR cells. Amitriptyline (15 μM) causes a stimulation of ERK1/2 phosphorylation in C6 cells. Amitriptyline (30 μM) inhibits Forskolin-stimulated adenylyl cyclase activity and antagonizes (−)-U50,488 inhibitory effect in rat nucleus accumbens. [5] Amitriptyline binds the extracellular domain of both TrkA and TrkB and promotes TrkA-TrkB receptor heterodimerization. Amitriptyline (< 500 nM) promotes TrkA autophosphorylation in primary neurons and induces neurite outgrowth in PC12 cells. Amitriptyline selectively protects T17 cells from apoptosis with EC50 of 50 nM. [6] |
| 体内活性 | Amitriptyline (15 mg/kg, i.p.) activates TrkA and TrkB receptors and significantly reduces kainic acid-triggered neuronal cell death in mice. [6] Amitriptyline (15 mg/kg and 30 mg/kg, i.p.) dose-dependently decreases the immobility time in the forced swimming test (FST) of mice. Amitriptyline (15 mg/kg, i.p.) shows a significant 24-h rhythm in the immobility time in the forced swimming test (FST) of mice. [7] Amitriptyline (1 mg/kg and 3 mg/kg) significantly increases the total distance travelled of mice in novel cages. Amitriptyline (10 mg/kg p.o., twice daily) considerably attenuates the hypothermic response to 8-OHDPAT and mCPP in mice. Amitriptyline (10 mg/kg p.o., twice daily) significantly reduces serotonin transporter density by approximately 20% in cortex of mice. [8] |
| CAS | 549-18-8 |
| 纯度 | 97% |
| 分子量 | 313.86 |
| 分子式 | C20H24ClN |
| 溶解度 | DMSO: 59 mg/mL (188 mM) Ethanol: 59 mg/mL (188 mM) Water: 12 mg/mL (38.2 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble ) |
| 储存温度 | 0-4℃ for short term (days to weeks), or -20℃ for long term (months). |
| 品牌 | MBC |
作为众多知名品牌的合作伙伴，昀冠以专业技术和热情服务与您携手建立战略合作。
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用
