MBC
(1R,9S,E)-4,11,11-三甲基-8-亚甲基双环[7.2.0]十一烷基-4-烯|β-Caryophyllene
| PB00182-25g
純度: 90%
![(1R,9S,E)-4,11,11-三甲基-8-亚甲基双环[7.2.0]十一烷基-4-烯](/upload/product/cas/600/87-44-5.jpg)
M0703-83956
PB00182-25g
25g
87-44-5
C15H24
90%
¥83.00
¥58.00
1
3 天
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- 产品详情
昀冠品质提供的(1R,9S,E)-4,11,11-三甲基-8-亚甲基双环[7.2.0]十一烷基-4-烯 MBC(PB00182-25g) 性能卓越，竭诚为您服务。
| 英文名称* | β-Caryophyllene |
|---|---|
| 中文名称 | (1R,9S,E)-4,11,11-三甲基-8-亚甲基双环[7.2.0]十一烷基-4-烯 |
| 别名 | (-)-(E)-Caryophyllene, (?)-β-caryophyllene, (?)-trans-Caryophyllene |
| 产品描述 | β-Caryophyllene is a CB2 receptor agonist. |
| 靶点活性 | CB2 |
| 体外活性 | Among the tested cancer cells, β-Caryophyllene demonstrates selective anti-proliferative effect against three cancer cell lines, namely HCT 116 (colon cancer, IC50=19 μM), PANC-1 (pancreatic cancer, IC50=27 μM), and HT29 (colon cancer, IC50=63 μM) cells, whereas β-Caryophyllene exhibits either moderate or poor cytotoxic effects against ME-180, PC3, K562 and MCF-7. Results show that β-Caryophyllene possesses higher selectivity towards the colorectal cancer cells (HCT 116), with selectivity index (SI)=27.9, followed by PANC-1 and HT 29 cells with SI=19.6 and 8, respectively. The apoptotic index estimated for β-Caryophyllene treatment on HCT 116 cells after 24 h treatment is 64±0.04. β-Caryophyllene at 10 μM concentration, causes significant nuclei condensation after 6 h of treatment. β-caryophyllene exhibits a dose and time-dependent inhibitory effect on the motility of HCT 116 cells. |
| 体内活性 | Treatment with β-Caryophyllene at different doses does not show any effects on swimming speed during the test. Oral treatment with β-Caryophyllene ameliorates the rise in β-amyloid deposition in the transgenic mice in a roughly dose-dependent manner, and the two higher doses exhibit almost equal effects in modifying the β-amyloid burden. The number of activated astroglial cells is higher in vehicle-treated mouse brains than in β-Caryophyllene-treated mouse brains with different doses. β-Caryophyllene is effective at reducing the enhancement of the COX-2 protein level found in vehicle-treated APP/PS1 mice. Animals treated with β-Caryophyllene display higher values of object recognition index than their vehicle-treated counterparts [t(14)=4.204, P<0.05]. The total time spent in object exploration during the test trial is not significantly different between β-Caryophyllene-treated and vehicle-treated animals (t(14)=0.5874, P>0.05). Treatment with β-Caryophyllene does not significantly alter these seizure-induced neurochemical changes. |
| CAS | 87-44-5 |
| 纯度 | 90% |
| 分子量 | 204.35 |
| 分子式 | C15H24 |
| 溶解度 | Ethanol: 176.67 mg/mL (864.55 mM) H2O: < 0.1 mg/mL (insoluble) DMSO: < 1 mg/mL (insoluble or slightly soluble) ( < 1 mg/ml refers to the product slightly soluble or insoluble ) |
| 储存温度 | 0-4℃ for short term (days to weeks), or -20℃ for long term (months). |
| 品牌 | MBC |
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