MBC
腺苷-5'-三磷酸二钠盐(ATP)|Adenosine 5'-triphosphate disodium salt
| PB00623-100g
纯度:99+% ； 分子式:C10H14N5O13P3·2Na
M0703-84825
PB00623-100g
100g
987-65-5
C10H14N5O13P3·2Na
99+%
¥694.00
¥270.00
1
3 天
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| 英文名称* | Adenosine 5'-triphosphate disodium salt |
|---|---|
| 中文名称 | 腺苷-5'-三磷酸二钠盐(ATP) |
| 别名 | ATP disodium salt, Disodium adenosine triphosphate, ATP, Adenosine-Triphosphate, ATP disodium, Adetide |
| 产品描述 | Adenosine 5'-triphosphate disodium salt is a P2 purinoceptor agonist. |
| 靶点活性 | Others |
| 体外活性 | ATP release and autocrine feedback through P2Y2 and A3 receptors provide signal amplification, controlling gradient sensing and migration of neutrophils. [1] ATP results in production of reactive oxygen species (ROS), which stimulates the phosphatidylinositol 3-kinase (PI3K) pathway and subsequent Akt and ERK1/2 activation. ATP-dependent ROS production and PI3K activation also stimulate transcription of genes required for an oxidative stress response. ATP-mediated ROS-dependent PI3K is required for activation of caspase-1 and secretion of IL-1beta and IL-18. [2] ATP potently stimulates TNF-alpha release, resulting from TNF-alpha mRNA expression in rat cultured brain microglia. ATP-induced TNF-alpha release is Ca(2+)-dependent, and a sustained Ca(2+) influx correlated with the TNF-alpha release in ATP-stimulated microglia. ATP-induced TNF-alpha release is inhibited by PD 098059, an inhibitor of extracellular signal-regulated protein kinase (ERK) kinase 1 (MEK1), which activates ERK, and also by SB 203580, an inhibitor of p38 mitogen-activated protein kinase. ATP rapidly activates both ERK and p38 even in the absence of extracellular Ca(2+). [3] ATP-induced cytotoxicity is mediated by classical alterations of apoptosis, including membrane blebbing, nuclear condensation, and DNA fragmentation. ATP but not other nucleotides lead to the potent and selective activation of NF-κB in microglial cells through a P2Z receptor-mediated pathway. [4] |
| 体内活性 | ATP regulates microglial branch dynamics in the intact mice brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglial response towards injury. [5] |
| CAS | 987-65-5 |
| 纯度 | 99+% |
| 分子量 | 551.14 |
| 分子式 | C10H14N5O13P3·2Na |
| 溶解度 | Water: 10 mM DMSO: Insoluble ( < 1 mg/ml refers to the product slightly soluble or insoluble ) |
| 储存温度 | 0-4℃ for short term (days to weeks), or -20℃ for long term (months). |
| 品牌 | MBC |
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